Matrix Gla protein deficiency impairs nasal septum growth, causing midface hypoplasia
نویسندگان
چکیده
منابع مشابه
Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 deficiency.
Hereditary haemorrhagic telangiectasia (HHT), also referred to as the Osler–Weber–Rendu syndrome, is characterised by multiple arteriovenous malformations (AVMs) in different organs including lungs, brain, liver, intestine and spleen [1]. Five types of HHT have been identified [1]. Mutations in the gene for the activin receptor-like kinase 1 (Alk1), a bone morphogenetic protein (BMP) type I rec...
متن کاملMatrix Gla protein deficiency causes arteriovenous malformations in mice.
Arteriovenous malformations (AVMs) in organs, such as the lungs, intestine, and brain, are characteristic of hereditary hemorrhagic telangiectasia (HHT), a disease caused by mutations in activin-like kinase receptor 1 (ALK1), which is an essential receptor in angiogenesis, or endoglin. Matrix Gla protein (MGP) is an antagonist of BMPs that is highly expressed in lungs and kidneys and is regulat...
متن کاملMatrix Gla protein in tumoral pathology
Matrix Gla protein is a vitamin K-dependent protein secreted by chondrocytes and vascular smooth muscle cells. The presence of matrix Gla protein was reported in arterial and venous walls, lungs, kidney, uterus, heart, tooth cementum and eyes. Several studies identified matrix Gla protein in tumoral pathology. Until recently, it was thought to only have an inhibitory role of physiological and e...
متن کاملMatrix Gla protein reinforces angiogenic resolution.
Matrix Gla Protein (MGP) is an ECM molecule commonly associated with dysfunctions of large blood vessels such as arteriosclerosis and atherosclerosis. However, the exact role of MGP in the microvasculature is not clear. Utilizing a mouse MGP knockout model we found that MGP suppresses angiogenic sprouting from mouse aorta restricts microvascular density in cardiac and skeletal muscle, and is an...
متن کاملGrowth Arrest-specific 6 Protein and Matrix Gla Protein in Hemodialysis Patients.
INTRODUCTION Plasma protein growth arrest-specific 6 (GAS6) and matrix Gla protein (MGP) are crucial mediators of vascular calcification and are involved in the development of vascular complications in chronic kidney diseases. This study was set out to investigate the relationship between plasma GAS6 levels and MGP in patients with end-stage renal disease on maintenance hemodialysis. MATERIAL...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2017
ISSN: 0021-9258
DOI: 10.1074/jbc.m116.769802